Thermo Fisher Scientific Phospho-Tau (Ser579) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Tau only when phosphorylated at Ser579, a site historically referenced as Ser262.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms of Tau contribute to cytoskeletal plasticity, while longer isoforms stabilize microtubules. In its hyper-phosphorylated form, Tau constitutes the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation impairs Tau’s microtubule-binding ability, leading to microtubule destabilization and neuronal degeneration in AD. Tau phosphorylation is mediated by multiple kinases, including GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau is also associated with other neurodegenerative diseases such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.