Thermo Fisher Scientific Phospho-Tau (Thr529) Polyclonal Antibody

Thermo Fisher Scientific Phospho-Tau (Thr529) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Tau only when phosphorylated at Thr529, a site historically referenced as Thr212.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.

Axonal polarity is determined by TAU/MAPT localization within neuronal cells. Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the major component of neurofibrillary lesions in Alzheimer’s disease (AD). This phosphorylation impairs microtubule binding, leading to neuronal degeneration. Tau is phosphorylated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other CNS disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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