Thermo Fisher Scientific Phospho-Tau (Ser721) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Tau only when phosphorylated at Ser721, a site historically referenced as Ser404.

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures.

Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize the structure. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease (AD). This modification disrupts Tau’s microtubule-binding function, leading to neuronal degeneration. Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is associated with neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.