Thermo Fisher Scientific GALE Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.5–1 µg/mL
• Publications: References

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions:

• Epimerization of UDP-glucose to UDP-galactose
• Epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine

The bifunctional nature of the enzyme leads to metabolic consequences where mutant cells depend on exogenous galactose and N-acetylgalactosamine for glycoprotein and glycolipid synthesis.
Mutations in this gene cause epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with severity ranging from mild (peripheral form) to severe (generalized form).
Multiple alternatively spliced transcripts encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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