Thermo Fisher Scientific CD3 Monoclonal Antibody (1F4), Biotin
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA516460 | - | Thermo Fisher Scientific MA516460 CD3 Monoclonal Antibody (1F4), Biotin 100 ug pk | 재고문의 | pk | 0원 | - | 0원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Flow Cytometry (Flow)
Neat-1:10
Product Specifications
Host/Isotype
Mouse / IgM
Class
Monoclonal
Type
Antibody
Clone
1F4
Immunogen
F344 rat T cells stimulated with PMA (TPA) and calcium ionophore if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
CD3,
uniProtId:
P19377-1,
ncbiNodeId:
10114,
antigenRange:
1-173,
antigenLength:
173,
antigenImageFileName:
MA5-16460_CD3_P19377-1_House_mouse.svg,
antigenImageFileNamePDP:
MA5-16460_CD3_P19377-1_House_mouse_PDP.jpeg,
sortOrder:
11},{
targetFamily:
CD3,
uniProtId:
Q64159-1,
ncbiNodeId:
10114,
antigenRange:
1-182,
antigenLength:
182,
antigenImageFileName:
MA5-16460_CD3_Q64159-1_House_mouse.svg,
antigenImageFileNamePDP:
MA5-16460_CD3_Q64159-1_House_mouse_PDP.jpeg,
sortOrder:
12}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Biotin Biotin Biotin
View additional formats
Form
Liquid
Concentration
0.1 mg/mL
Storage conditions
4°C or -20°C if preferred
Shipping conditions
Wet ice
RRID
AB_2537975
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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