ELK Biotechnology NDE1 rabbit pAb
NDE1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에서 반응하며 세포골격 및 중심체 단백질 연구에 유용합니다. 고순도 IgG 형태로 -20°C에서 1년간 보관 가능합니다.
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제품명
NDE1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 270–350) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| GeneID (Human) | 54820 |
| Human Swiss-Prot No | Q9NXR1 |
| Storage | -20°C / 1 year |
| Source | Rabbit |
세포 내 위치
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow.
Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis.
배경 정보
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function.
This protein plays an essential role in microtubule organization, mitosis, and neuronal migration. Mutations in this gene cause lissencephaly 4, characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation.
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
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