Thermo Fisher Scientific Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Monoclonal Antibody (LHK6 (LHK6B))
Cytokeratin 6 단백질을 인식하는 고특이성 mouse monoclonal antibody. IHC, ICC, Flow Cytometry 등 다양한 면역분석에 사용 가능. Human 및 Mouse 반응성. Protein A/G 정제, PBS buffer에 보존.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.1–0.2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LHK6 (LHK6B) |
| Immunogen | Synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keratin 6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Keratins 6 and 16 are expressed in keratinocytes undergoing rapid turnover in the suprabasal region, known as hyperproliferation-related keratins.
Keratin 6 is found in hair follicles, suprabasal cells of various internal stratified epithelia, and epidermis, in both normal and hyperproliferative states.
Epidermal injury activates keratinocytes expressing CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas, and its expression is associated with differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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