Thermo Fisher Scientific Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Monoclonal Antibody (MBP/4276)
MBP Thr98 인산화 형태를 인식하는 mouse monoclonal antibody로, oligodendrocyte 및 myelin 표지자로 사용됩니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A/G 정제 및 PBS 기반 안정적 저장 조건을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MBP/4276 |
| Immunogen | Synthetic peptide corresponding to human MBP phosphorylated at threonine 98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also found in bone marrow and the immune system. These arise from the long MBP gene (also called Golli-MBP) which includes three additional upstream exons.
Alternative splicing produces two families of transcripts:
- Golli-MBP transcripts — contain unique Golli exons fused to MBP exons, encoding hybrid proteins with N-terminal Golli and MBP sequences.
- Classic MBP transcripts — include only MBP exons, producing well-characterized myelin basic proteins.
This conserved gene structure suggests MBP is an integral part of the Golli transcription unit, important for regulation and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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