Thermo Fisher Scientific Myelin Basic Protein Monoclonal Antibody (MBP/4275)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: Human brain or astrocytoma tissue
• Cellular Location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side (of myelin)

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (also called Golli-MBP) that contains three additional exons located upstream of the classic MBP exons.
Alternative splicing from the Golli and MBP transcription start sites gives rise to two sets of MBP-related transcripts and gene products. The Golli mRNAs contain three exons unique to Golli-MBP, spliced in-frame to one or more MBP exons. They encode hybrid proteins that have N-terminal Golli amino acid sequences linked to MBP sequences.
The second family of transcripts contains only MBP exons and produces the well-characterized myelin basic proteins. This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.