Thermo Fisher Scientific CYP1A2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified, His-tagged, full length human P450 1A2 fusion protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP1A2,uniProtId:P05177-1,ncbiNodeId:9606,antigenRange:1-516,antigenLength:516,antigenImageFileName:PA1-341_CYP1A2_P05177-1_Rabbit.svg,antigenImageFileNamePDP:PA1-341_CYP1A2_P05177-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2292570

Product Specific Information

PA1-341 detects cytochrome P450 (P450) 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms.

PA1-341 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~56 kDa protein representing recombinant human P450 1A2.

The PA1-341 immunogen is purified, His-tagged, full length human P450 1A2 fusion protein.

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3 untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.