Thermo Fisher Scientific CYP1A1 Polyclonal Antibody
Human CYP1A1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunocytochemistry에 적합. His-tagged full-length human P450 1A1 항원을 면역원으로 사용. Protein G 정제, PBS buffer, 0.05% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | View publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified, His-tagged, full-length human P450 1A1 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325602 |
Product Specific Information
PA1-340 detects cytochrome P450 (P450) 1A1 from human cells.
This antibody detects, to a lesser extent, other P450 isoforms.
PA1-340 has been successfully used in Western blot procedures.
By Western blot, this antibody detects an ~54 kDa protein representing P450 1A1 from MCF-7 cell extract.
The PA1-340 immunogen is purified, His-tagged, full-length human P450 1A1 fusion protein.
Target Information
The CYP1A1 gene encodes a member of the cytochrome P450 superfamily of enzymes.
Cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and its expression is induced by certain polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
Although the enzyme’s endogenous substrate is unknown, it can metabolize some PAHs to carcinogenic intermediates.
The gene is associated with lung cancer risk.
A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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