Thermo Fisher Scientific CYP1A1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-340 detects cytochrome P450 (P450) 1A1 from human cells.
This antibody detects, to a lesser extent, other P450 isoforms.

PA1-340 has been successfully used in Western blot procedures.
By Western blot, this antibody detects an ~54 kDa protein representing P450 1A1 from MCF-7 cell extract.

The PA1-340 immunogen is purified, His-tagged, full-length human P450 1A1 fusion protein.

Target Information

The CYP1A1 gene encodes a member of the cytochrome P450 superfamily of enzymes.
Cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and its expression is induced by certain polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
Although the enzyme’s endogenous substrate is unknown, it can metabolize some PAHs to carcinogenic intermediates.
The gene is associated with lung cancer risk.
A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.