Thermo Fisher Scientific CYP1A1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

1:250

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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified, His-tagged, full length human P450 1A1 fusion protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP1A1,uniProtId:P04798-1,ncbiNodeId:9606,antigenRange:1-512,antigenLength:512,antigenImageFileName:PA1-340_CYP1A1_P04798-1_Rabbit.svg,antigenImageFileNamePDP:PA1-340_CYP1A1_P04798-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_325602

Product Specific Information

PA1-340 detects cytochrome P450 (P450) 1A1 from human cells. This antibody detects, to a lesser extent, other P450 isoforms.

PA1-340 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~54 kDa protein representing P450 1A1 from MCF-7 cell extract.

The PA1-340 immunogen is purified, His-tagged, full length human P450 1A1 fusion protein.

Target Information

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme`s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.