Thermo Fisher Scientific Phospho-MEKK1 (Thr1402) Polyclonal Antibody
Phospho-MEKK1 (Thr1402) 폴리클로날 항체로 인간 및 랫트에서 반응 예측됨. WB, IHC, ELISA에 적합하며 고순도 Rabbit IgG 포맷. MAPK 신호전달 연구용. 액상 형태로 -20°C 보관, 동결·해동 반복 피함.
- 판매단위
- pk
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human MEK Kinase-1 around the phosphorylation site of T1402 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608553 |
Product Specific Information
This antibody is predicted to react with human and rat based on sequence homology.
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells.
MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2), leading to phosphorylation of MAP kinases.
It is also a highly efficient activator of the JNK cascade.
The protein contains a putative RING-type zinc finger and a SWIM-type zinc finger.
주의사항
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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