Thermo Fisher Scientific mGluR2/mGluR3 Polyclonal Antibody
Thermo Fisher Scientific의 mGluR2/mGluR3 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 장기 보관 시 -20°C에서 안정적입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 836–872 of Human mGluR-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553567 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of approximately 95 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors).
The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways.
Activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
The remaining subtypes of mGluR have activity mediated by a G-protein that inhibits adenylate cyclase activity.
mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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