Thermo Fisher Scientific NOC3L Polyclonal Antibody
Rabbit polyclonal antibody targeting human NOC3L for WB applications. Reacts with Human, Mouse, and Rat. Detects endogenous 93 kDa protein with >95% purity. Supplied as liquid, unconjugated form, 1 mg/mL concentration. For research use only.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 417–436 of human NOC3L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long term, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553556 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 93 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
GADD153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein also known as CHOP-10 or C/EBP zeta. Expression is induced by cellular stresses such as nutrient deprivation and metabolic perturbations. GADD153 blocks cell cycle progression from G1 to S phase by dimerizing with other C/EBP proteins, directing dimers to nonclassical binding sites. It acts as a negative modulator of C/EBP-like proteins in terminally differentiated cells.
NOC3L, also designated factor for adipocyte differentiation 24 (Fad24), promotes adipogenesis by controlling DNA replication during early stages of mitotic clonal expansion (MCE).
GADD153 belongs to the CBF/MAK21 family, which includes NOC2L, NOC3L, and NOC4L.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-36501_NOC3L_Q8WTT2-1_Rabbit.svg, PA5-36501_NOC3L_Q8WTT2-1_Rabbit_PDP.jpeg)
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