Thermo Fisher Scientific CD204 Polyclonal Antibody
CD204 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용에 최적화.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | View 1 publication |
| Flow Cytometry (Flow) | 2–5 µg/million cells | - |
| in situ PLA (PLA) | Assay-Dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to an internal portion of the human protein (within residues 400–450). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.00 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154270 |
Product Specific Information
Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), human liver protein.
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors are macrophage-specific trimeric integral membrane glycoproteins involved in macrophage-associated physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms type 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
- Isoform type 3 does not internalize modified LDL and is trapped within the endoplasmic reticulum.
- Isoform type 3 can inhibit the function of isoforms type 1 and 2, suggesting a regulatory mechanism for scavenger receptor activity in macrophages.
- Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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