Thermo Fisher Scientific HMGB2 Polyclonal Antibody
Rabbit polyclonal antibody against HMGB2 protein. Validated for IHC (Paraffin). Recognizes human, mouse, and rat HMGB2. Affinity purified with >95% purity. Suitable for research use in chromatin and DNA repair studies.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 136–180 of Human HMGB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2718956 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. These chromatin-associated proteins are ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have shown that HMGB2 efficiently bends DNA and forms DNA circles, suggesting a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. HMGB2 is also involved in the final ligation step in DNA end-joining processes, including double-strand break repair and V(D)J recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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