Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Paraffin)에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제되어 고순도(>95%)를 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids at the N-terminus of Human CDK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718959 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the family of cyclin-dependent kinases (CDKs), which are critical regulators of cell cycle progression. Members such as p34/Cdc2 and Cdk2 act late in the cycle, while Cdk4 and Cdk6 regulate G1 to S transition. Human Cdk8–Cyclin C complex may interact with RNA polymerase, influencing transcription mechanisms that lead to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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