Thermo Fisher Scientific MLLT10 Polyclonal Antibody
MLLT10 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, IHC(P) 및 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간, 마우스, 랫트에 반응합니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 200–250 of Human MLLT10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718963 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Translocations affecting chromosome 11q23 involve multiple partner chromosome regions and occur in various leukemias. The 11q23 gene involved in these translocations is MLL, and MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations.
MLLT10 encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. It can also rearrange independently with the CALM gene in the t(10;11)(p12;q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 retain the leucine zipper motif of MLLT10, which interacts with GAS41, a protein associated with chromatin remodeling complexes. This interaction suggests that these fusion proteins may disrupt normal gene regulation through chromatin remodeling interference.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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