Thermo Fisher Scientific CaV3.1 Monoclonal Antibody (N178A/9), PerCP

Thermo Fisher Scientific CaV3.1 Monoclonal Antibody (N178A/9), PerCP

Applications and Tested Dilutions

• Western Blot (WB): 1:1,000
• Immunohistochemistry (IHC): Assay-dependent
• Immunocytochemistry (ICC/IF): 1:100

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

1 µg/mL of MA5-45545 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately <200 kDa. Does not cross-react with Cav3.2.
This antibody was formerly sold as clone S178A-9.

Target Information

Voltage-dependent Ca²⁺ channels mediate calcium entry into excitable cells in response to membrane depolarization. They participate in various Ca²⁺-dependent processes such as muscle contraction, hormone or neurotransmitter release, and gene expression.
Calcium channels are multimeric complexes composed of:

• α1 subunit
• intracellular β subunit
• disulfide-linked α2/δ subunit
• transmembrane γ subunit

Ca²⁺ currents are classified by biophysical and pharmacologic properties: L-, N-, T-, P-, Q-, and R-types.
T-type Ca²⁺ currents are activated and inactivated more rapidly and at lower membrane potentials than other types.
T-type channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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