Thermo Fisher Scientific Nav1.6 Polyclonal Antibody
Nav1.6 (SCN8A) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적 유지. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of mouse Nav1.6 (SCN8A) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and human.
- Specificity of this antibody: SCN8A.
Target Information
The sodium channel protein type 8 subunit alpha (Na⁺ CP type VIII alpha) is a multi-pass transmembrane protein that mediates sodium ion permeability of excitable membranes.
Voltage-gated sodium channel proteins consist of:
- A pore-forming alpha subunit
- A noncovalently associated beta1 subunit
- A disulfide-linked beta2 subunit
The beta subunits regulate channel expression, modulate gating, and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction.
Alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons.
Sodium channels are essential for rapid signal transduction and neuronal development.
Defects in the SCN8A gene can lead to impaired growth of secondary motoneurons, progressive paralysis, and early death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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