Thermo Fisher Scientific UPF1 Polyclonal Antibody
UPF1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, ICC/IF, ELISA, IP에 적합합니다. Human, Mouse, Rat에 반응하며 PBS/glycerol 완충액에 보관됩니다. NMD 관련 연구 및 세포 내 단백질 발현 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 819–1118 of human UPF1/RENT1 (NP_0029022) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806006 |
Product Specific Information
- Positive Samples: 293T, SH-SY5Y, K-562, HL-60, Mouse liver
- Cellular Location: Cytoplasm, Nucleus, P-body
Immunogen sequence:
QEVEIASVDA FQGREKDFII LSCVRANEHQ GIGFLNDPRR LNVALTRARY GVIIVGNPKA LSKQPLWNHL LNYYKEQKVL VEGPLNNLRE SLMQFSKPRK LVNTINPGAR FMTTAMYDAR EAIIPGSVYD RSSQGRPSSM YFQTHDQIGM ISAGPSHVAA MNIPIPFNLV MPPMPPPGYF GQANGPAAGR GTPKGKTGRG GRQKNRFGLP GPSQTNLPNS QASQDVASQP FSQGALTQGY ISMSQPSQMS QPGLSQPELS QDSYLGDEFK SQIDVALSQD STYQGERAYQ HGGVTGLSQY
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons.
It functions as an ATP-dependent RNA helicase located in the cytoplasm and is also a component of cytoplasmic P-bodies.
Upf1 phosphorylation mediates translation repression during NMD, enabling mRNA accessibility to the degradation machinery.
Other NMD components include Upf2 and Upf3, which exhibit perinuclear and nucleocytoplasmic localization, respectively.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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