Thermo Fisher Scientific CD326 (EpCAM) Monoclonal Antibody (G8.8), PerCP-eFluor 710, eBioscience
CD326(EpCAM) 항체(G8.8)는 마우스 유래 단클론 항체로 PerCP-eFluor 710 형광체가 결합되어 있으며, 유세포분석(Flow Cytometry)에 적합합니다. EpCAM을 표적으로 하며, 상피세포 및 암세포 연구에 활용됩니다. 488 nm 레이저로 여기되어 710 nm에서 방출됩니다.
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Applications
- Tested Application: Flow Cytometry (Flow)
- Tested Dilution: 0.06 µg/test
- Publications: View 57 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PerCP-eFluor 710, eBioscience |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G8.8 |
| Conjugate | PerCP-eFluor 710 |
| Excitation / Emission Max | 482 / 708 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10597602 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant Violet 711
- Brilliant Violet 786
- eFluor 450
- FITC
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The G8.8 monoclonal antibody reacts with the 40 kDa mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40, 17-1A antigen, TACSTD1, and CD326.
Generated using the TE-71 thymic epithelial cell line, CD326 is expressed on most epithelial cells and functions as a pan-carcinoma antigen mediating calcium-independent, homophilic cell-cell adhesion. It may also act as a growth factor receptor and is a target for immunotherapy in human carcinomas. CD326 binds LAIR-1 (CD305) and LAIR-2 (CD306), modulating cellular activation and inflammation.
- Reported Application: Flow cytometric analysis
- Tested Application: Flow cytometric analysis of TE-71 cell line
- Recommended Usage: ≤ 0.06 µg/test (100 µL final volume; 10⁵–10⁸ cells/test)
- Fluorochrome: PerCP-eFluor 710 (excitation 488 nm, emission 710 nm, Blue Laser)
- Recommended Filters: 685 LP dichroic mirror and 710/40 band pass (695/40 acceptable)
- Fixation Stability: Stable after 2% formaldehyde fixation overnight at 4°C
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Ep-CAM (Epithelial Cell Adhesion Molecule) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It mediates Ca²⁺-independent, homotypic cell adhesion and influences cell cycle, proliferation, and metabolism by inducing c-myc and cyclins A/E.
Ep-CAM overexpression is associated with enhanced epithelial proliferation and is a marker for tumors of epithelial origin. It is localized on the basolateral surface of most simple epithelia and many carcinoma types and is useful in distinguishing adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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