Thermo Fisher Scientific Phospho-TRIM28 (Ser824) Recombinant Rabbit Monoclonal Antibody (6H11L46)
Phospho-TRIM28 (Ser824)을 인식하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합. 높은 특이성과 재현성을 제공하며, 단백질 인산화 연구에 유용. Protein A로 정제된 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| Flow Cytometry (Flow) | 5 µg / 1M cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6H11L46 |
| Immunogen | Peptide corresponding to human Phospho-TRIM28 (Ser824) [aa819–aa827] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2688287 |
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, and Rat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The KRAB (Kruppel-associated box) domain, approximately 45 amino acids in length, is a transcriptional repression domain found in numerous transcription factors. Over 220 KRAB-zinc finger protein (KRAB-ZFP) genes have been identified in the human genome.
These proteins repress transcription via interactions with KAP-1 (KRAB-associated protein 1), an 835 amino acid polypeptide containing RING finger, B boxes, and PHD finger domains. KAP-1 forms complexes with KRAB-domain transcription factors to enhance repression efficiency and interacts directly with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 targets KRAZ1 to centromeric heterochromatin regions containing HP1alpha, thereby regulating transcriptional repression. Mutant KAP-1 unable to bind HP1 leads to random KRAZ1 distribution and strong transcriptional activation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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