Thermo Fisher Scientific Phospho-Rb (Ser807, Ser811) Recombinant Rabbit Monoclonal Antibody (13H27L9)
Recombinant rabbit monoclonal antibody specific for Phospho-Rb (Ser807/Ser811). Validated for WB and ICC/IF. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for human samples; predicted reactivity with monk...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 13H27L9 |
| Immunogen | Peptide corresponding to human Phospho-Rb (Ser807/Ser811) [aa805–aa814] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2688292 |
Product Specific Information
This antibody is predicted to react with monkey, bovine, and pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues and forms complexes with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may regulate transcription, and loss of its function can lead to uncontrolled cell growth. Aberrations in the RB gene are implicated in cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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