Thermo Fisher Scientific STAT2 Recombinant Rabbit Monoclonal Antibody (4A5P8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4A5P8

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 550-706 of human STAT2 (NP_0054101) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STAT2,uniProtId:P52630-3,ncbiNodeId:9606,antigenRange:550-706,antigenLength:851,antigenImageFileName:MA5-42828_STAT2_P52630-3_Rabbit.svg,antigenImageFileNamePDP:MA5-42828_STAT2_P52630-3_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2911969

Product Specific Information

Immunogen sequence: KLPFWTWLDK ILELVHDHLK DLWNDGRIMG FVSRSQERRL LKKTMSGTFL LRFSESSEGG ITCSWVEHQD DDKVLIYSVQ PYTKEVLQSL PLTEIIRHYQ LLTEENIPEN PLRFLYPRIP RDEAFGCYYQ EKVNLQERRK YLKHRLIVVS NRQVDEL; Positive test controls include: A-549, U-937, Mouse brain, Rat testis. The target is usually found in the following locations: Cytoplasm, Nucleus.

Target Information

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.