Thermo Fisher Scientific DNAI1 Recombinant Rabbit Monoclonal Antibody (4Y6Q1)
Recombinant rabbit monoclonal antibody (clone 4Y6Q1) specific for DNAI1. Validated for WB and ELISA in mouse and rat samples. Supplied as liquid, unconjugated, 1.1 mg/mL concentration. For research use only, not for diagnostic applications.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4Y6Q1 |
| Immunogen | Recombinant fusion protein corresponding to amino acids 1–200 of human Dynein intermediate chain 1 (Q9UI46) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911973 |
Product Specific Information
Positive test controls include:
- Mouse lung
- Mouse testis
- Rat testis
Immunogen sequence:
MIPASAKAPH KQPHKQSISI GRGTRKRDED SGTEVGEGTD EWAQSKATVR PPDQLELTDA ELKEEFTRIL TANNPHAPQN IVRYSFKEGT YKPIGFVNQL AVHYTQVGNL IPKDSDEGRR QHYRDELVAG SQESVKVISE TGNLEEDEEP KELETEPGSQ TDVPAAGAAE KVTEEELMTP KQPKERKLTN QFNFSERASQ
Target Information
Eukaryotic cells rely on actin and microtubule-based protein motors to generate intracellular movements. These protein motors contain specialized domains that hydrolyze ATP to produce force and movement along cytoskeletal polymers (actin for myosin family, microtubules for kinesin and dynein families).
Dynein is involved in cytoplasmic motile functions, including:
- Chromosomal movement
- Retrograde organelle and axonal transport
- Endocytic pathway
- Golgi apparatus organization
Dynein complexes consist of two or three heavy chains (~450 kDa), three intermediate chains (70–125 kDa), and at least four light chains (15–25 kDa).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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