Thermo Fisher Scientific CD30 Monoclonal Antibody (mCD30.1), PE, eBioscience
마우스 CD30 항원을 인식하는 PE 결합 단클론 항체로, Flow Cytometry 분석에 최적화됨. Armenian hamster IgG 아이소타입, 0.2 mg/mL 농도. 488–561 nm 여기, 578 nm 방출 특성. 활성화된 T세포 연구 및 면역조절 기전 분석에 적합.
- 카탈로그번호
- 12-0301-82
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD30 Monoclonal Antibody (mCD30.1), PE, eBioscience
Thermo Fisher Scientific CD30 Monoclonal Antibody (mCD30.1), PE, eBioscience
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 1 µg/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | mCD30.1 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465629 |
Additional Formats
Product Specific Information
The mCD30.1 monoclonal antibody reacts with mouse CD30, a 105–120 kDa member of the TNFR superfamily.
CD30 is not detectable on splenocytes but can be upregulated on T cells stimulated in vitro through TCR, peaking around day 4–5 post-activation. It is expressed by both CD8⁺ and CD4⁺ activated cells and is suggested to regulate cytokine secretion and T cell development.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Tested on resting and activated mouse splenocytes at ≤1 µg/test
- Recommended Use: Carefully titrate for optimal performance
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily.
Originally identified on Hodgkin’s and Reed-Sternberg cells using monoclonal antibody Ki-1, its ligand is CD30L (CD153). CD30-CD30L interaction mediates cell proliferation, activation, differentiation, and apoptotic cell death.
CD30 plays a critical role in:
- Hodgkin’s disease and CD30⁺ lymphomas
- Thymic negative selection as a costimulatory molecule
- Expression on activated T and B cells, virus-infected lymphocytes, and embryonal carcinomas
Soluble CD30 (sCD30) serves as a marker of Th2 immune response.
TRAF2 and TRAF5 interact with CD30, activating NF-κB signaling.
It acts as a positive regulator of apoptosis, limiting autoreactive CD8 effector T cells and preventing autoimmunity.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.