Thermo Fisher Scientific mGluR3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human mGluR3, validated for WB, IHC(P), and ICC/IF. High specificity due to synthetic peptide immunogen from N-terminal domain. Supplied unconjugated in PBS with sodium azide, 1 mg/mL concentration. Suitable for neu...
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Thermo Fisher Scientific mGluR3 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 9 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM3 / MGLUR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551189 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant (100%)
Rat, Hamster, Panda (94%)
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. Initially, it was known to act only on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors, which mediate fast excitatory synaptic transmission.
Recent studies show that glutamate also regulates enzymes producing second messengers via specific G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs).
- Group I receptors (mGluR1a, mGluR5): Stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
- Group II and III receptors (mGluR2, mGluR3): Inhibit adenylyl cyclase.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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