Thermo Fisher Scientific Phospho-ATM (Ser1981) Monoclonal Antibody (3F10)

Applications and Tested Dilutions

Product Specifications

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene encodes a protein of the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and targets downstream regulators such as P53, Mdm2, BRCA1, and SMC1.

ATM plays a crucial role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shows extensive homology to the catalytic domains of PI3 kinases. Studies have demonstrated that ATM becomes autophosphorylated and activated upon exposure to ionizing radiation. Cells lacking functional ATM are hypersensitive to radiation, display impaired DNA synthesis inhibition, and delayed p53 induction. DNA damage activates ATM kinase, initiating a cascade of reactions regulating cell cycle, apoptosis, and DNA repair. ATM has also been linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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