Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (LH1), eBioscience
마우스 HVEM(TNFRSF14)을 인식하는 LH1 단클론 항체로, Flow Cytometry 및 기능적 분석에 적합합니다. 0.25 µg/test 농도로 사용 가능하며, 0.5 mg/mL 액상 형태로 제공됩니다. 4°C 보관, PBS(pH 7.2) 버퍼 및 0.09% sodium azide 포함.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg/test
- View 1 publication
Functional Assay (Functional)
- Tested Dilution: Assay-Dependent
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_953630 |
Additional Formats
Product Specific Information
Description:
The LH1 monoclonal antibody reacts with mouse Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is expressed on T cells, B cells, monocytes, neutrophils, and dendritic cells. It acts as a cellular mediator for herpes simplex virus (HSV) entry through binding of viral envelope glycoprotein D (gD). The cytoplasmic region of HVEM interacts with TRAF family members, mediating immune response signaling. HVEM also serves as a ligand for BTLA, suggesting a conserved regulatory pathway in lymphocyte activation and homeostasis.
The LH1 antibody functions as a blocking antibody, interfering with HVEM-LIGHT interaction but not HVEM-BTLA interaction.
Applications Reported:
Reported for use in flow cytometric analysis and functional assays.
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended use ≤ 0.25 µg/test (100 µL final volume). Cell number may range from 10⁵ to 10⁸ cells/test. Antibody titration is recommended for optimal performance.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
TNFRSF14 (HVEM):
A member of the TNF-receptor superfamily and a mediator of HSV entry via glycoprotein D binding. The cytoplasmic region binds TRAF family members, activating immune signaling pathways. Activation in T cells promotes proliferation and cytokine production, contributing to inflammation and CTL-mediated tumor immunity. Multiple alternatively spliced variants exist, though full-length sequences of some remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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