Thermo Fisher Scientific Phospho-VEGF Receptor 1 (Tyr1213) Polyclonal Antibody
VEGFR1의 Tyr1213 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FLT1 (Accession P17948), corresponding to amino acid residues around phosphorylated Tyr1213. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818295 |
Product Specific Information
This antibody detects endogenous levels of VEGFR1 only when phosphorylated at Tyrosine 1213.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase that plays a critical role in angiogenesis. Active angiogenesis is involved in various physiological and pathological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation, while promoting endothelial cell proliferation and angiogenesis in adulthood in a cell-type specific manner.
It has high affinity for VEGFA but relatively low kinase activity, possibly functioning as a negative regulator of VEGFA signaling by limiting free VEGFA availability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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