Thermo Fisher Scientific Phospho-HDAC8 (Ser39) Polyclonal Antibody
Phospho-HDAC8 (Ser39) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%) 및 안정적 액상 형태로 제공되어 연구용으로 최적화된 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human HDAC8 around the phosphorylation site of Serine 39 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553636 |
Product Specific Information
- Detects endogenous protein at molecular weights of 42 and 73 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, largely influenced by histone acetylation and deacetylation. Acetylation of lysine residues enhances DNA accessibility to transcription factors, while deacetylation is linked to transcriptional silencing.
Several mammalian histone acetylases have been identified, including GCN5, PCAF, p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase with distinct tissue distribution. HDAC8 is localized to the nucleus and plays a role in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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