Thermo Fisher Scientific Phospho-IKK beta (Tyr188) Polyclonal Antibody
Phospho-IKK beta (Tyr188) 항체로 인간, 생쥐, 랫트 시료에 반응하며 Western blot 및 IHC(P) 분석에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체로 NF-κB 신호전달 연구에 유용. 장기보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyrosine 188 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553638 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 86 kDa.
- Purity is greater than 95% by SDS-PAGE.
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential in NF-kappa-B signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
It functions within the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on two critical serine residues, leading to their polyubiquitination and degradation. This releases NF-kappa-B, which translocates to the nucleus to activate genes involved in immune response, growth control, and protection against apoptosis.
Mutations in the IKK beta gene can cause Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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