
Thermo Fisher Scientific Phospho-Tau (Thr231) Recombinant Superclonal Antibody (1HCLC)
Phospho-Tau (Thr231) 표적을 인식하는 Thermo Fisher Scientific의 Recombinant Superclonal 항체로, 높은 특이성과 감도를 제공. Western blot, IHC, ICC/IF에 사용 가능. 재조합 기술로 로트 간 일관성 유지. 신경퇴행성 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 1HCLC |
| Immunogen | Phosphopeptide corresponding to amino acids 224–236 of human microtubule-associated protein tau |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532578 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They comprise multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, and ensuring consistent performance across lots.
These antibodies recognize multiple epitope sites on the target, providing enhanced detection sensitivity for low-abundance targets.
Formerly called “Recombinant polyclonal antibody,” this product is now rebranded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.
Target Information
Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules.
Hyper-phosphorylated Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease.
Phosphorylation impairs Tau’s microtubule binding, leading to neuronal degeneration.
Tau abnormalities are associated with Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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