Thermo Fisher Scientific JAK2 Polyclonal Antibody
JAK2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. WB, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 고순도 Affinity Chromatography 정제 및 안정적 PBS/glycerol 저장. 세포 내 JAK2 위치 및 신호 전달 연구에 적합.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 933–1132 of human JAK2 (NP_004963.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.54 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913695 |
Product Specific Information
Positive test controls include: C6, Mouse brain, Mouse lung.
The target is usually found in the following locations: Cytoplasm, Endomembrane system, Nucleus, Peripheral membrane protein.
Immunogen sequence:
PYGSLRDYLQ KHKERIDHIK LLQYTSQICK GMEYLGTKRY IHRDLATRNI LVENENRVKI GDFGLTKVLP QDKEYYKVKE PGESPIFWYA PESLTESKFS VASDVWSFGV VLYELFTYIE KSKSPPAEFM RMIGNDKQGQ MIVFHLIELL KNNGRLPRPD GCPDEIYMIM TECWNNNVNQ RPSFRDLALR VDQIRDNMAG
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera.
This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated genes.
JAK2 is required for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier. Mutations in JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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