Thermo Fisher Scientific PYCARD Polyclonal Antibody
Thermo Fisher Scientific의 PYCARD 폴리클로날 항체는 인간, 마우스, 랫트 반응성을 가지며 세포사멸 및 염증 연구에 적합합니다. Western blot, IHC, ICC/IF, ELISA에 사용 가능하며 고순도 친화 크로마토그래피 정제 제품입니다. PBS/glycerol 버퍼에 보관하며 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–195 of human ASC/TMS1 (NP_0373902) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913703 |
Product Specific Information
Positive test controls include: Mouse spleen, Rat spleen.
Localization: Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus.
Immunogen sequence:
LDLTDKLVSF YLETYGAELT ANVLRDMGLQ EMAGQLQAAT HQGSGAAPAG IQAPPQSAAK PGLHFIDQHR AALIARVTNV EWLLDALYGK VLTDEQYQAV RAEPTNPSKM RKLFSFTPAW NWTCKDLLLQ ALRESQSYLV EDLERS
Target Information
Functions as a key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving caspase-8 and caspase-9. Participates in activation of the mitochondrial apoptotic pathway and mediates mitochondrial translocation of BAX. Plays a central role in macrophage pyroptosis and inflammasome assembly, activating caspase-1 and promoting secretion of proinflammatory cytokines. Involved in both innate and adaptive immune responses, regulating NF-κB, MAPK, and caspase-8 signaling. Isoforms may modulate inflammasome activity and interleukin-1β maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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