Thermo Fisher Scientific MSR1 Monoclonal Antibody (OTI1F10), TrueMAB
MSR1 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 적합합니다. 인간 유래 MSR1 단백질(aa 197-451)을 면역원으로 제작되었으며, 동결건조 상태로 제공됩니다. 연구용으로 사용되며, -20°C에서 보관이 권장됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 197–451 of human MSR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, which include three isoforms (types 1, 2, and 3) generated by alternative splicing. These macrophage-specific trimeric integral membrane glycoproteins are involved in processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
- Isoform 3 does not internalize LDLs and is retained in the endoplasmic reticulum.
- Isoform 3 may inhibit the function of isoforms 1 and 2, suggesting a regulatory mechanism for scavenger receptor activity.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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