Thermo Fisher Scientific MSR1 Monoclonal Antibody (OTI8C11), TrueMAB
MSR1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 IHC(P) 분석에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공되어 안정적 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C11 |
| Immunogen | Human recombinant protein fragment (aa 197–451 of human MSR1) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, including three isoforms (1, 2, 3) generated by alternative splicing.
These macrophage-specific trimeric integral membrane glycoproteins are involved in physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms 1 and 2: Functional receptors mediating endocytosis of modified LDLs.
- Isoform 3: Retained in the endoplasmic reticulum, unable to perform endocytosis; exhibits dominant negative regulation of isoforms 1 and 2.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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