Thermo Fisher Scientific MSR1 Monoclonal Antibody (OTI5F9), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting prior to use (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, which include three isoforms (types 1, 2, and 3) generated by alternative splicing. These macrophage-specific trimeric integral membrane glycoproteins are implicated in various macrophage-associated physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.

• Isoforms 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
• Isoform 3, although containing the same functional domain, is retained in the endoplasmic reticulum and cannot perform endocytosis.
• Isoform 3 can inhibit the function of isoforms 1 and 2 when co-expressed, suggesting a regulatory mechanism for scavenger receptor activity in macrophages.
  Diseases associated with MSR1 include Barrett’s Esophagus and Prostate Cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.