Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Recombinant Rabbit Monoclonal Antibody (SATB2/8877R)
사람 SATB2 단백질을 인식하는 재조합 토끼 단클론 항체로, 결장암 표지자 연구에 적합. IHC(P)에서 1-2 µg/mL로 사용. 핵 내 위치 단백질 검출에 유용하며, Protein A/G 정제 및 PBS 완충액에 보존. 연구용 전용 제품.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SATB2/8877R |
| Immunogen | Recombinant fragment (around aa200–300) of human SATB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human colon or cerebral cortex tissue
- Cellular Location: Nucleus
Target Information
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions. It recognizes the sugar-phosphate backbone of double-stranded DNA and functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and remodeling local chromatin loops.
SATB2 acts as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers. It is essential for initiating upper-layer neuron (UL1) gene programs and repressing deep-layer (DL) and UL2-specific genes, likely through modulation of BCL11B expression.
Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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