Thermo Fisher Scientific Interleukin-1beta (IL-1beta) Monoclonal Antibody (IL1B/3993)
사람 IL-1β를 인식하는 단클론 항체로, 염증성 사이토카인 연구에 적합합니다. IHC, ELISA 등 다양한 응용에 사용 가능하며, Protein A/G 정제 및 무보존제 PBS 용액 형태입니다. 냉동(-20°C) 보관을 권장합니다.
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- 3553-MSM6-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| ELISA | Assay-dependent | |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1B/3993 |
| Immunogen | Recombinant fragment of human IL1B protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved to the active 17 kDa form upon inflammasome activation. The active form is secreted via a non-classical pathway. IL-1β signals through IL-1RI and IL-1RII, receptors shared with IL-1α, and its activity can be inhibited by IL-1 Receptor Antagonist (IL-1RA). IL-1β is a key mediator in innate immunity and inflammation, and elevated levels are associated with chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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