Thermo Fisher Scientific Interleukin-1beta (IL-1beta) Monoclonal Antibody (IL1B/465)
인간 IL-1β를 인식하는 mouse monoclonal antibody로, IHC, ICC/IF 및 ELISA에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 4°C 보관. 염증 반응 연구 및 IL-1β 신호전달 분석에 적합.
- 카탈로그번호
- 3553-MSM7-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Interleukin-1beta (IL-1beta) Monoclonal Antibody (IL1B/465)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1B/465 |
| Immunogen | Recombinant full-length human IL1B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa protein through inflammasome activation. Inflammasomes activate caspase-1, which processes pro-IL-1β into its mature form. IL-1β lacks a signal peptide and is secreted via a non-classical pathway alongside caspase-1. It signals through IL-1RI and IL-1RII receptors, shared with IL-1α, and its activity can be inhibited by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a crucial role in innate immunity and inflammation, and elevated levels are associated with chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.