Thermo Fisher Scientific LILRA3 Polyclonal Antibody

Applications

• Flow Cytometry (Flow): 0.25 µg per million cells

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 30% cross-reactivity with recombinant human ILT2, ILT4, ILT5 is observed.
• Less than 5% cross-reactivity with rhLIR5 and rhLIR7.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer (NK) cells.
All LIRs in subfamily B have an inhibitory function (e.g., LILRB1, MIM 604811).
LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (e.g., LILRA1, MIM 604810).
One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.