Thermo Fisher Scientific BCL10 Monoclonal Antibody (OTI9C2), TrueMAB
인간 BCL10 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. TrueMAB 형식의 Mouse IgG1 항체이며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C2 |
| Immunogen | Full-length human recombinant protein of human BCL10 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-κB via NIK and IKK.
BCL-10 serves as an adapter between the upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex, and is a substrate for MALT1.
Mutations in the BCL10 gene may lead to Immunodeficiency 37 or mucosa-associated lymphoid lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(해당 제품 관련 이미지: CF800518_BCL-10_O95999-1_House_mouse_PDP.jpeg)
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