Thermo Fisher Scientific CD4 Monoclonal Antibody (OTI2H8), TrueMAB

Applications

• Western Blot (WB): 1:4,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882) for optimal results.

Target Information

The CD4 antigen plays a crucial role in recognizing MHC class II molecules and serves as a co-receptor for HIV. It is primarily expressed in T-helper cells but also found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression is observed in thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut.
CD4 contributes to T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Lck, and may mediate neuronal damage in infectious or immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified for this gene (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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