Thermo Fisher Scientific CD230 (PrP) Recombinant Rabbit Monoclonal Antibody (SC57-05)
CD230 (PrP) 단백질을 검출하기 위한 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, Flow Cytometry 등에 적용 가능. 높은 특이성과 재현성 제공. 인간, 마우스, 랫트 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific CD230 (PrP) Recombinant Rabbit Monoclonal Antibody (SC57-05)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:800 | 1 publication |
| Flow Cytometry (Flow) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC57-05 |
| Immunogen | Synthetic peptide within Human Prion Protein aa 200–249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809489 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal production candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
Human prion protein (PrP), also known as PRNP, is a GPI-anchored cell surface glycoprotein associated with lipid rafts and functions as a signaling molecule. PrP is involved in apoptosis, epithelial cell proliferation, and junction-associated protein distribution in enterocytes.
Conversion of normal PrPc into abnormal PrPSc is the key event in prion neurodegenerative diseases such as Creutzfeld-Jakob disease (CJD). PrPc is rich in alpha-helices, while PrPSc has increased beta-sheet content and resistance to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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