Thermo Fisher Scientific p53 Monoclonal Antibody (OTI9A7), TrueMAB

Thermo Fisher Scientific p53 Monoclonal Antibody (OTI9A7), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation.
p53 regulates transcription of genes such as p21waf1, contributing to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is key for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation.
p53 plays crucial roles in preventing proliferation of damaged cells, aging, oxidative stress, and memory-related processes.
Mutations in TP53 lead to loss of tumor suppressor function and are common in many cancers, including hereditary Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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