Thermo Fisher Scientific IL21R Polyclonal Antibody
IL21R 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. WB와 IHC(P)에서 검증됨. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피로 정제. 세포막 위치 단백질 검출에 적합.
- 카탈로그번호
- PA5119919
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:600 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human IL-21R aa 51–100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913491 |
Product Specific Information
- Positive Control: Rat spleen tissue lysate, rat liver tissue lysate, rat thymus tissue lysate, mouse spleen tissue lysate, mouse thymus tissue lysate, Daudi cell lysate, human spleen tissue
- Subcellular Location: Membrane
Target Information
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptor family and forms a heterodimeric receptor complex with the common gamma-chain, shared by IL2 and IL5 receptors. This receptor mediates IL21-induced growth signals, crucial for T cell, B cell, and NK cell proliferation and differentiation. Ligand binding activates downstream signaling molecules including JAK1, JAK3, STAT1, and STAT3. Knockout studies in mice suggest involvement in immunoglobulin regulation. Three alternatively spliced transcript variants encoding the same protein are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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