Thermo Fisher Scientific GATM Monoclonal Antibody (2H7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

MLRVRCLRGG SRGAEAVHYI GSRLGRTLTG WVQRTFQSTQ AATASSRNSC 
AADDKATEPL PKDCPVSSYN EWDPLEEVIV GRAENACVPP FTIEVKANTY

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family.
Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure.

AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm.
It is biallelically expressed in placenta and fetal tissues and expressed in brain, heart, liver, lung, salivary gland, and skeletal muscle, with high expression in kidney.
AGAT is elevated in myocardium during heart failure and decreased in inter-uterine growth restriction (IUGR)-associated placenta.

AGAT catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency — an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, and severe depletion of creatine/phosphocreatine in the brain.
AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.