Thermo Fisher Scientific GBA Monoclonal Antibody (2E2)
GBA 단백질을 인식하는 마우스 모노클로날 항체로 Western blot, IHC, ICC, ELISA 등에 사용 가능. 인간 시료 반응성. PBS 용액 내 보존, 무보존제. Gaucher 병 관련 연구에 적합.
- 카탈로그번호
- H00002629-M01
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E2 |
| Immunogen | GBA (NP_000148, 146 a.a. approximately 235 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SYFSEEGIGY NIIRVPMASC DFSIRTYTYA DTPDDFQLHN FSLPEEDTKL KIPLIHRALQ LAQRPVSLLA SPWTSPTWLK TNGAVNGKGS
Target Information
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disorder characterized by accumulation of glucocerebrosides. A related pseudogene is located approximately 12 kb downstream on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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